Rabbit Secondary Antibodies
Immunoreagents Inc RABBIT A-HUMAN IGG DYLIGHT594
Secondary Antibody; Rabbit anti-human IgG (H&L) - Affinity Pure, DyLight 594 Conjugate, Host: Rabbit, Format: Lyo, Label: DyL594, Applications: WB, ELISA, IHC/ICC, IF, IP, FC, FACS
ABclonal Technology 594 Rabbit anti-Human CD8b
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 beta chain isoforms Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described A pseudogene also located on chromosome 2 has been identified
ABclonal Technology APC Rabbit anti-Human CD33 mAb
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology 488 Rabbit anti-Human CD9
This gene encodes a member of the transmembrane 4 superfamily also known as the tetraspanin family Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins The encoded protein functions in many cellular processes including differentiation adhesion and signal transduction and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis
ABclonal Technology 488 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology PE Rabbit anti-Human CD42b mAb
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer an alpha chain and a beta chain that is linked by disulfide bonds The Gp Ib functions as a receptor for von Willebrand factor (VWF) The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis This gene encodes the alpha subunit Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy
ABclonal Technology 450 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 647 Rabbit anti-Human FATP1
Enables biotin transmembrane transporter activity efflux transmembrane transporter activity and long-chain fatty acid transporter activity Involved in several processes including carboxylic acid transmembrane transport glycerophospholipid biosynthetic process and lipid transport across blood-brain barrier Located in membrane Part of plasma membrane
ABclonal Technology 488 Rabbit anti-Human IL8
The protein encoded by this gene interleukin-8 (IL-8) is a CXC chemokine and major mediator of the inflammatory response IL-8 is secreted by various cells including macrophages neutrophils and T lymphocytes and acts as a chemotactic factor guiding neutrophils to infection sites It is rapidly induced by bacterial and viral products and plays a role in systemic inflammatory response syndrome (SIRS) IL-8 contributes to bronchiolitis caused by respiratory syncytial virus (RSV) and is involved in lung inflammation in cystic fibrosis It is also linked to coronary artery disease endothelial dysfunction and promotes tumor migration angiogenesis and metastasis IL-8 binds to the CXCR2 receptor increasing blood vessel permeability Elevated IL-8 levels correlate with disease severity including sepsis This gene is part of a CXC chemokine gene cluster on chromosome 4q
ABclonal Technology 488 Rabbit anti-Human CD48
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 488 Rabbit anti-Human MRC2
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer gliomas and metastatic bone disease
ABclonal Technology 488 Rabbit anti-Human CD11a
ITGAL encodes the integrin alpha L chain Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1) which is expressed on all leukocytes LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAMs 1-3 (intercellular adhesion molecules 1 through 3) and also functions in lymphocyte costimulatory signaling Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD44 mAb
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions cell adhesion and migration It is a receptor for hyaluronic acid (HA) and can also interact with other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs) This protein participates in a wide variety of cellular functions including lymphocyte activation recirculation and homing hematopoiesis and tumor metastasis Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms however the full length nature of some of these variants has not been determined Alternative splicing is the basis for the structural and functional diversity of this protein and may be related to tumor metastasis